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Resveratrol abrogates adhesion molecules and protects against TNBS-induced ulcerative colitis in rats

Dalaal M Abdallah1, Naglaa R Ismael

  • 1Department of Pharmacology and Toxicology, Cairo University, Egypt.

Canadian Journal of Physiology and Pharmacology
|October 28, 2011
PubMed

Insights

Resveratrol demonstrates significant anti-ulcerative effects in experimental colitis. It reduces inflammation and oxidative stress, showing promise as a therapeutic agent for ulcerative colitis.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Biochemistry

Background:

  • Resveratrol, a polyphenol, exhibits anti-inflammatory properties.
  • Previous studies suggest resveratrol's benefits in ulcerative colitis models.
  • The current study investigates its effects on adhesion molecules and antioxidant efficacy.

Purpose of the Study:

  • To elucidate the effect of resveratrol on adhesion molecules in TNBS-induced ulcerative colitis.
  • To evaluate the antioxidant efficacy of resveratrol in this model.
  • To compare resveratrol's efficacy with sulphasalazine.

Main Methods:

  • Ulcerative colitis induced by trinitrobenzene sulfonic acid (TNBS) in rats.
  • Daily oral administration of sulphasalazine (300 mg/kg) or resveratrol (2 and 10 mg/kg) for 7 days.
  • Assessment of ulcerative area, colon mass index, inflammation, histopathology, myeloperoxidase activity, ICAM-1, VCAM-1, nitric oxide, lipid peroxides, and glutathione levels.

Main Results:

  • Resveratrol significantly decreased ulcerative area, colon mass index, and inflammation.
  • It reduced myeloperoxidase activity and suppressed ICAM-1 and VCAM-1 levels.
  • Resveratrol restored nitric oxide levels and redox balance by reducing lipid peroxides and preventing glutathione depletion.
  • The higher dose of resveratrol showed efficacy comparable to sulphasalazine.

Conclusions:

  • Resveratrol exhibits significant anti-ulcerative effects in TNBS-induced colitis.
  • Its efficacy is mediated by reduced neutrophil infiltration and inhibition of adhesion molecules.
  • Resveratrol also restores nitric oxide levels and improves redox status, confirming its therapeutic potential.

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