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Continuation rate of combined hormonal contraception: a prospective multicenter study
Iñaki Lete1, Ezequiel Pérez-Campos, Marta Correa
1Service of Gynecology, Hospital Santiago Apóstol, Vitoria-Gasteiz, Spain. ilete@hsan.osakidetza.net
Journal of Women'S Health (2002)
|October 28, 2011
Summary
The combined pill and vaginal ring showed similar continuation rates and effectiveness in typical users over 12 cycles. These methods were significantly more effective than the skin patch for combined hormonal contraception.
Area of Science:
- Reproductive Health
- Clinical Pharmacology
- Women's Health
Background:
- Clinical trial data on contraceptive use may not reflect real-world scenarios.
- A study was needed to evaluate combined hormonal contraceptive methods among typical users.
Purpose of the Study:
- To assess continuation rates at 12 cycles for combined hormonal contraceptives.
- To determine reasons for discontinuation and calculate the Pearl index.
Main Methods:
- Prospective, observational, multicenter study.
- 3443 women aged 18-49 years using vaginal ring, pill, or skin patch.
- Intention-to-treat analysis.
Main Results:
- Continuation rates at 12 cycles: pill (45.9%), vaginal ring (42.3%), skin patch (26.0%).
- Pearl index: pill (0.61), vaginal ring (0.61), skin patch (2.34).
- Significant difference in Pearl index between skin patch and other methods (p<0.001).
Conclusions:
- The vaginal ring and pill have comparable continuation rates and effectiveness.
- Both the pill and vaginal ring are significantly more effective than the skin patch at 12 cycles.
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