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Composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma
Sho Yamazaki1, Yosei Fujioka, Fumihiko Nakamura
1Department of Hematology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Pathology International
|October 28, 2011
Summary
This case study details a rare composite lymphoma involving diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma not otherwise specified. Effective treatment with R-CHOP chemotherapy was observed, even with widespread disease.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Composite lymphoma involves two or more distinct lymphoma types in one site.
- Composite B-cell and T-cell lymphomas are exceptionally rare.
Observation:
- A 66-year-old female presented with lymphadenopathy, bone lesions, and an epidural tumor.
- Biopsied lymph node revealed dual populations: large B-cells (DLBCL) and medium T-cells (PTCL-NOS).
- Immunophenotyping confirmed DLBCL and CD20-positive PTCL-NOS.
Findings:
- The patient was diagnosed with composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma not otherwise specified.
- Complete remission was achieved after six cycles of R-CHOP chemotherapy.
- This is the first reported case of CD20-positive PTCL-NOS in a composite lymphoma.
Implications:
- This rare entity may respond well to systemic chemotherapy despite extranodal involvement.
- Highlights the importance of accurate diagnosis in complex lymphoma cases.
- Contributes to understanding rare lymphoma subtypes and treatment outcomes.
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