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Updated: May 28, 2026
Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production
Published on: October 26, 2018
Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation
Matthias Glaser1, Julian Goggi, Graham Smith
1MDx Discovery (Part of GE Healthcare), Hammersmith Imanet Ltd, Hammersmith Hospital, London, United Kingdom. matthias.glaser@ge.com
Abstract:
We improved the specific radioactivity of the apoptosis imaging isatin derivative (18)F-ICMT11. We then evaluated (18)F-ICMT11 in EL4 tumor-bearing mice 24h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PET imaging demonstrated increased uptake in the drug-treated (0.115±0.011 SUV) compared to the vehicle-treated EL4 tumors (0.083±0.008 SUV). This effect correlated to the observed increases in apoptotic index.
