[Arrhythmogenic cardiomyopathy. Patterns of ventricular involvement using cardiac magnetic resonance]

Begoña Igual1, Esther Zorio, Alicia Maceira

  • 1Unidad de Imagen Cardiaca, ERESA, Unidad de Muerte Súbita Familiar, Hospital Universitari i Politècnic La Fe, Valencia, España. bigual@eresa.com

Insights

Left ventricle involvement is common in arrhythmogenic cardiomyopathy, with late gadolinium enhancement frequently observed. This study used cardiovascular magnetic resonance to detail ventricular patterns and enhancement in these conditions.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Medical Diagnostics

Context:

  • Arrhythmogenic cardiomyopathy (ACM) spectrum now includes biventricular and left dominant forms.
  • Understanding ventricular involvement patterns is crucial for diagnosis and management.
  • Cardiovascular magnetic resonance (CMR) is a key imaging modality for ACM.

Purpose:

  • To describe ventricular involvement patterns using CMR.
  • To characterize late gadolinium enhancement (LGE) in ACM variants.
  • To investigate patterns in biventricular and left dominant ACM.

Summary:

  • CMR revealed left ventricle (LV) involvement in 92% of ACM patients, predominantly with LGE.
  • Right ventricle (RV) involvement occurred in 73%, with varying degrees of dysfunction and LGE.
  • LV LGE was most common in inferior, lateral, and inferolateral walls, often subepicardial or transmural.

Impact:

  • Highlights the high prevalence of LV involvement in ACM.
  • Provides detailed insights into LGE patterns, aiding diagnostic accuracy.
  • Informs clinical understanding and potential therapeutic strategies for ACM.
Abstract

Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...