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Updated: May 28, 2026

Examination of Host Phenotypes in Gambusia affinis Following Antibiotic Treatment

Examination of Host Phenotypes in Gambusia affinis Following Antibiotic Treatment

Published on: February 22, 2017

Salmonella, the host and its microbiota.

Parameth Thiennimitr¹, Sebastian E Winter, Andreas J Bäumler

¹Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA, United States.

Current Opinion in Microbiology

|October 28, 2011

Summary

Salmonella Typhimurium exploits host inflammation during gastroenteritis to outcompete beneficial gut bacteria. Understanding this pathogen

Area of Science:

Microbiology
Gastroenterology
Immunology

Background:

The intestinal microbiota is crucial for gut health.
Its structure is maintained by unknown mechanisms.
Enteric pathogens disrupt this balance.

Purpose of the Study:

To investigate how Salmonella Typhimurium alters the gut bacterial community structure during gastroenteritis.
To elucidate mechanisms by which pathogens manipulate the host response.

Main Methods:

Studies involving Salmonella Typhimurium infection in a host model.
Analysis of bacterial community structure shifts.
Investigation of host inflammatory responses.

Main Results:

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Last Updated: May 28, 2026

Examination of Host Phenotypes in Gambusia affinis Following Antibiotic Treatment

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Salmonella Typhimurium outgrowth observed during acute inflammation.

Pathogen leverages host response to displace beneficial bacteria.

Significant alterations in gut microbiota composition documented.

Conclusions:

Salmonella Typhimurium actively reshapes the gut microbiota during infection.
Host inflammatory responses can be co-opted by pathogens.
Insights gained into host-microbiota dynamics during gastroenteritis.