Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Potassium currents in hippocampal pyramidal cells.

J F Storm1

  • 1Institute of Neurophysiology, Oslo 1, Norway.

Progress in Brain Research
|January 1, 1990
PubMed
Summary

Mammalian neurons utilize multiple potassium currents for electrical signaling. This study details six distinct voltage- or calcium-dependent potassium currents in hippocampal pyramidal cells, crucial for neuronal function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Capacity for consciousness under ketamine anaesthesia is selectively associated with activity in posteromedial cortex in rats.

Neuroscience of consciousness·2022
Same author

General Anesthesia Disrupts Complex Cortical Dynamics in Response to Intracranial Electrical Stimulation in Rats.

eNeuro·2021
Same author

Two distinct pools of large-conductance calcium-activated potassium channels in the somatic plasma membrane of central principal neurons.

Neuroscience·2010
Same author

Kv7/KCNQ/M-channels in rat glutamatergic hippocampal axons and their role in regulation of excitability and transmitter release.

The Journal of physiology·2006
Same author

Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency.

Proceedings of the National Academy of Sciences of the United States of America·2004
Same author

BK channel activity determines the extent of cell degeneration after oxygen and glucose deprivation: a study in organotypical hippocampal slice cultures.

Neuroscience·2002

Area of Science:

  • Neuroscience
  • Cellular Electrophysiology

Background:

  • Hippocampal pyramidal cells exhibit complex electrical properties due to co-existing potassium currents.
  • Understanding these currents is vital for comprehending neuronal excitability and information processing in the central nervous system.

Purpose of the Study:

  • To characterize the diverse voltage- and calcium-dependent potassium currents in mammalian hippocampal pyramidal neurons.
  • To elucidate the specific roles of individual potassium currents in neuronal firing patterns and signal integration.

Main Methods:

  • Electrophysiological recordings from CA1 and CA3 pyramidal neurons in rat and guinea-pig hippocampal slices, cell cultures, and acutely dissociated cells.
  • Analysis of current activation, inactivation kinetics, and voltage dependence.

Main Results:

  • Six distinct potassium currents (IA, ID, IK, IM, IC, IAHP) were identified and characterized.
  • IA and ID contribute to spike repolarization and regulate firing patterns with different kinetics.
  • IK, IM, IC, and IAHP are involved in repolarization, adaptation, and after-hyperpolarizations, with varying sensitivities to calcium and pharmacological agents.

Conclusions:

  • Hippocampal pyramidal cells employ a sophisticated repertoire of potassium currents to precisely control their electrical activity.
  • These currents play critical roles in shaping action potentials, regulating firing frequency, and integrating synaptic inputs.

Related Experiment Videos