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Related Experiment Video

Updated: May 28, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Extraneous tissue: a potential source for diagnostic error in surgical pathology.

Lester J Layfield1, Benjamin L Witt, Kenneth G Metzger

  • 1Dept of Pathology, 1950 Circle of Hope, Salt Lake City, UT 84112, USA.

American Journal of Clinical Pathology
|October 28, 2011
PubMed
Summary

Floaters, extraneous material on histology slides, can cause diagnostic errors. Identifying them by location and tissue type mismatch is crucial for accurate pathology diagnoses.

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Last Updated: May 28, 2026

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Area of Science:

  • Histopathology
  • Diagnostic Pathology
  • Laboratory Science

Background:

  • Extraneous material, termed "floaters," can be introduced during tissue processing and slide preparation.
  • These floaters pose a significant risk for diagnostic errors in histopathology.

Purpose of the Study:

  • To determine the frequency of floaters in histological slides.
  • To identify features that aid in the recognition of floaters.

Main Methods:

  • Review of quality assurance (QA) records for floaters in over 500,000 slides.
  • Prospective examination of 1,000 additional slides for floaters, documenting their characteristics.
  • Analysis of floater size, location, and presence across tissue sections.

Main Results:

  • Floaters were detected in 0.01% to 1.2% of slides.
  • The majority of floaters (approximately 60%) were likely picked up from the water bath.
  • Floaters present in only a single tissue level or mismatched with the specimen tissue type were key indicators.

Conclusions:

  • Floaters are an uncommon but important artifact in histopathology.
  • Recognizing floaters based on their location and tissue type is essential to prevent misdiagnosis.
  • Water bath contamination is a primary source of floater artifacts.