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Multicentric osteosarcoma: clinicopathologic and radiographic study of 56 cases
Domenico Corradi1, Doris E Wenger, Franco Bertoni
1Dept. of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
American Journal of Clinical Pathology
|October 28, 2011
Summary
Multicentric osteosarcoma (M-OGS) involves multiple bone sites without organ spread. Aggressive surgery offers improved survival, especially for metachronous M-OGS cases.
Area of Science:
- Orthopedic Oncology
- Skeletal Pathology
Background:
- Multicentric osteosarcoma (M-OGS) is a rare variant characterized by multiple primary bone tumors.
- It presents synchronously or metachronously without distant organ metastasis.
Purpose of the Study:
- To conduct a clinicopathological and radiographic analysis of 56 Multicentric Osteosarcoma cases.
- To evaluate treatment outcomes and prognostic factors in M-OGS.
Main Methods:
- Retrospective analysis of 56 M-OGS cases (22 synchronous, 34 metachronous).
- Review of clinicopathological and radiographic data.
- Assessment of treatment modalities including surgery, chemotherapy, and radiotherapy.
Main Results:
- The distal femur was the most frequent primary site.
- All tumors were histologically high-grade.
- Synchronous M-OGS frequently involved the axial skeleton (64%).
- Metachronous M-OGS second tumors appeared after a median of 22 months.
- Long-term survival was observed in 8 patients treated with aggressive surgery and adjuvant therapies.
Conclusions:
- Multicentric osteosarcoma is a high-grade malignancy with a generally poor prognosis.
- Aggressive surgical resection with wide margins, combined with multimodal therapy, may improve long-term survival, particularly in metachronous cases.
