Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genomic DNA in Eukaryotes

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

Evolution of Microbial Genome

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

Diversity of Protists I

Diversity of Protists I

Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Host range expansion of asexual parasite can be explained by loss of adaptions in Muller's Ratchet.

Nature communications·2025

Same author

Analysis of Oesophagostomum dentatum excretory-secretory molecules and extracellular vesicles uncovers a repertoire of microRNAs shared with A. Suum and T. Suis and ES containing Paz and Piwi domain proteins implicated in RNAi signaling.

International journal for parasitology·2025

Same author

Illuminating the druggability of the Giardia duodenalis kinome through reannotation and high-throughput screens.

International journal for parasitology. Drugs and drug resistance·2025

Same author

Population structure, gene flow and genetic diversity of sheep blowfly (Lucilia cuprina dorsalis) in Australia.

BMC genomics·2025

Same author

Comparative genomic analysis of necrophagous and parasitic subspecies of Lucilia cuprina (Diptera: Calliphoridae) provides important insight into their divergent biologies.

International journal for parasitology·2025

Same author

Hookworms dynamically respond to loss of Type 2 immune pressure.

PLoS pathogens·2023

Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026

Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026

Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026

Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026

Same journal

Dementia risk in middle-aged people linked to a blood protein.

Nature·2026

Same journal

Daily briefing: What's really happening with trust in science.

Nature·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 28, 2026

Ultralow Input Genome Sequencing Library Preparation from a Single Tardigrade Specimen

Ultralow Input Genome Sequencing Library Preparation from a Single Tardigrade Specimen

Published on: July 15, 2018

Ascaris suum draft genome.

Aaron R Jex¹, Shiping Liu, Bo Li

¹Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010, Australia. ajex@unimelb.edu.au

|October 28, 2011

Summary

This summary is machine-generated.

The draft genome of Ascaris suum, a common roundworm, reveals key molecules for host tissue invasion and immune evasion. This resource aids in developing new treatments for ascariasis and other parasitic worm infections.

More Related Videos

Dissection of Mosquito Ovaries, Midgut, and Salivary Glands for Microbiome Analyses at the Organ Level

Dissection of Mosquito Ovaries, Midgut, and Salivary Glands for Microbiome Analyses at the Organ Level

Published on: October 4, 2024

Small-Scale Extraction of Caenorhabditis elegans Genomic DNA

Small-Scale Extraction of Caenorhabditis elegans Genomic DNA

Published on: June 7, 2022

Related Experiment Videos

Last Updated: May 28, 2026

Ultralow Input Genome Sequencing Library Preparation from a Single Tardigrade Specimen

Ultralow Input Genome Sequencing Library Preparation from a Single Tardigrade Specimen

Published on: July 15, 2018

Dissection of Mosquito Ovaries, Midgut, and Salivary Glands for Microbiome Analyses at the Organ Level

Dissection of Mosquito Ovaries, Midgut, and Salivary Glands for Microbiome Analyses at the Organ Level

Published on: October 4, 2024

Small-Scale Extraction of Caenorhabditis elegans Genomic DNA

Small-Scale Extraction of Caenorhabditis elegans Genomic DNA

Published on: June 7, 2022

Area of Science:

Parasitology
Genomics
Molecular Biology

Background:

Geohelminths like Ascaris infect over two billion people globally, causing significant mortality and disease burden.
Ascariasis impacts human health, particularly in children, leading to developmental issues and death, and also causes substantial losses in swine production.
The Ascaris-swine model is crucial for studying parasitic infections at a molecular level.

Purpose of the Study:

To sequence and analyze the draft genome of Ascaris suum.
To compare the Ascaris suum genome with other nematode genomes.
To identify molecules involved in host-parasite interactions and immune evasion.

Main Methods:

Whole-genome sequencing of Ascaris suum.
Bioinformatic analysis and comparison with other nematode genomes.
Secretome analysis to identify functional molecules.

Main Results:

A 273 megabase draft genome of Ascaris suum was generated, containing approximately 18,500 protein-coding genes.
The genome exhibits low repeat content (4.4%).
The A. suum secretome is rich in peptidases for tissue degradation and molecules for modulating host immune responses.

Conclusions:

The Ascaris suum genome provides a valuable resource for understanding parasitic diseases.
This genomic data will facilitate the development of novel interventions, including drugs, vaccines, and diagnostics, against ascariasis and other nematodiases.