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Hemangioma is associated with atopic disease
J Fredrik Grimmer1, Marc S Williams, Richard Pimentel
1Division of Otolaryngology, Department of Surgery, University of Utah, Salt Lake City, Utah, USA.
Summary
Infantile hemangioma is linked to a higher risk of atopic diseases like allergies, asthma, and eczema. Eczema showed the strongest association, nearly doubling the risk in children with hemangioma.
Area of Science:
- Dermatology
- Pediatrics
- Allergology
Background:
- Infantile hemangioma (IH) is a common vascular tumor in infants.
- Atopic diseases, including eczema, asthma, and allergies, are prevalent in childhood.
- The relationship between IH and atopic conditions requires further investigation.
Purpose of the Study:
- To investigate the association between infantile hemangioma and the occurrence of atopic diseases.
- To quantify the risk of allergies, asthma, and eczema in infants diagnosed with hemangioma.
Main Methods:
- A case-control study design was employed.
- Data were sourced from the Utah Population Database, including inpatient and outpatient records from 1991 to 2009.
- Logistic regression analysis compared atopic disease rates in 2063 hemangioma patients against matched controls.
Main Results:
- Patients with infantile hemangioma had a significantly higher odds ratio (1.67) for atopic disease (P < .0001).
- The hemangioma cohort exhibited increased risks for allergies (36%, P < .0001), asthma (67%, P < 4e-12), and eczema (82%, P < 2e-16).
- Eczema demonstrated the strongest association with infantile hemangioma, showing an almost 2-fold increased risk.
Conclusions:
- Atopic diseases, specifically allergies, asthma, and eczema, are positively associated with infantile hemangioma.
- The findings suggest a potential shared pathophysiology or common risk factors between infantile hemangioma and atopic conditions.
- Further research into this relationship may improve understanding and treatment strategies for both conditions.
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