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Updated: May 28, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Recurrent localized primary cutaneous marginal-zone B cell lymphoma.
Shoshana Marmon1, Julie Chu, Rishi Patel
1Department of Dermatology, New York University, New York, New York, USA.
Dermatology Online Journal
|October 28, 2011
Summary
A 36-year-old man experienced a recurrence of primary cutaneous marginal-zone B cell lymphoma. Clinicopathologic findings confirmed localized disease without extra-cutaneous involvement.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Primary cutaneous marginal-zone B cell lymphoma (PCMZL) is a rare, indolent non-Hodgkin lymphoma.
- Recurrence can manifest as new skin lesions, requiring careful diagnosis.
Observation:
- A patient with a history of PCMZL presented with new erythematous papules and nodules on his left arm and forearm.
- Skin biopsy revealed a lymphocytic infiltrate positive for CD20 and Bcl-2, but negative for CD10.
Findings:
- Positron emission tomography-computed tomography (PET-CT) scan excluded systemic or extra-cutaneous disease.
- Clinicopathologic correlation indicated a localized recurrence of PCMZL.
Implications:
- Early recognition of recurrent PCMZL is crucial for appropriate management.
- Localized recurrence suggests potential for effective treatment with targeted therapies or local interventions.
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