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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Inflammation01:38

Inflammation

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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Chemical leukoderma.

Kathryn E O'Reilly1, Utpal Patel, Julie Chu

  • 1Department of Dermatology, New York University, New York, New York, USA.

Dermatology Online Journal
|October 28, 2011
PubMed
Summary
This summary is machine-generated.

Chemical leukoderma, a skin condition from certain chemicals, can affect susceptible individuals. This case shows pyrethroid insecticides causing persistent leukoderma even after avoiding the chemical.

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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors
08:39

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Published on: January 7, 2019

Area of Science:

  • Dermatology
  • Toxicology

Background:

  • Chemical leukoderma is an acquired hypopigmented skin condition.
  • It arises from melanocyte destruction due to specific chemical exposures in susceptible individuals.
  • Lesions can appear at contact sites or remotely.

Observation:

  • This case involves chemical leukoderma caused by pyrethroid insecticides.
  • The condition persisted despite over ten years of avoiding the causative agent.

Findings:

  • Pyrethroid insecticides can induce persistent chemical leukoderma.
  • Avoidance alone may not be sufficient for repigmentation in some cases.
  • Treatments typically used for vitiligo might be necessary.

Implications:

  • Highlights the potential for long-term depigmentation from pyrethroid exposure.
  • Suggests a need for awareness among clinicians regarding insecticide-induced leukoderma.
  • Underscores the challenges in managing persistent chemical leukoderma.