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[Chemical constituents from the roots of Pithecellobium lucidum and their cytotoxic activity]
Shuanggang Ma1, Haining Lv, Guangzhi Ding
1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing 100050, China.
Abstract:
Six compounds were isolated from the roots of Pithecellobium lucidum by various chromatograhic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as julibroside A2 (1), 3-[ (2-acetamido-2-deoxy-beta-D-glucopyranosyl) oxy] -16alpha-hydroxyolean-12-en-28-oic acid (2), galloyl acid (3), ethyl gallate (4), (+)-catechin (5), (-)-gallocatechin gallate (6) on the basis of spectrascopic data analysis. Compounds 1-6 were isolated from Pithecellobium lucidum for the first time. Compound 2 showed selective cytoxic activity against the human cell lines A2780 with an IC50 value of 1.72 micromol x L(-1).