Related Experiment Video
Updated: May 28, 2026
09:52
Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)
Published on: April 19, 2013
IGF2BP2 genetic variation and type 2 diabetes: a global meta-analysis
Yuan Zhao1, Yu-Shui Ma, Ying Fang
1The Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
DNA and Cell Biology
|October 29, 2011
Summary
The rs4402960 polymorphism in the Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) gene is linked to an increased risk of type 2 diabetes (T2D). This association was confirmed across various ethnicities, particularly in East Asian, Caucasian, and Indian populations.
Area of Science:
- Genetics
- Metabolic Diseases
- Molecular Biology
Background:
- Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) plays a role in insulin action.
- Previous studies on IGF2BP2 gene polymorphisms and type 2 diabetes (T2D) risk have yielded conflicting results.
Purpose of the Study:
- To conduct a comprehensive meta-analysis to clarify the association between the rs4402960 polymorphism and T2D risk.
- To investigate potential variations in this association across different ethnic groups.
Main Methods:
- A meta-analysis was performed, pooling data from 35 studies.
- The analysis included a total of 70,261 T2D cases and 100,567 controls.
- Subgroup analyses were conducted based on ethnicity and other factors like sample size and BMI.
Main Results:
- The T variant of rs4402960 in IGF2BP2 was significantly associated with an elevated T2D risk (per-allele OR=1.14).
- Significant associations were observed for both heterozygous and homozygous genotypes compared to wild type.
- Increased risks were found in East Asian, Caucasian, and Indian populations, but not in others.
Conclusions:
- The rs4402960 polymorphism in IGF2BP2 is associated with an increased risk of T2D.
- The strength of this association varies among different ethnic populations.
Related Concept Videos
01:26Type II Diabetes I: Introduction
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
01:24Type II Diabetes II: Pathophysiology
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:26Type I Diabetes II: Pathophysiology
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
01:25Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
01:22Diabetes Mellitus: Overview and Type I Subtype
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...