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Updated: May 28, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Neurobrucellosis.

Osman Kizilkilic¹, Cem Calli

¹Department of Radiology, Cerrahpasa Medical Faculty, University of Istanbul, 34300 Kocamustafapasa, Istanbul. ebos90@hotmail.com

Neuroimaging Clinics of North America

|October 29, 2011

Summary

Neurobrucellosis, a nervous system complication of brucellosis, presents with varied symptoms and lacks specific diagnostic markers. Diagnosis relies on excluding other neurological conditions and identifying inflammation in cerebrospinal fluid.

Area of Science:

Neurology
Infectious Diseases
Medical Imaging

Background:

Brucellosis is a systemic infection with diverse clinical manifestations.
Neurobrucellosis (NB) is a neurological complication of brucellosis.
NB lacks a distinct clinical profile and specific cerebrospinal fluid (CSF) findings.

Purpose of the Study:

To outline the diagnostic criteria for neurobrucellosis.
To categorize the imaging findings associated with neurobrucellosis.

Main Methods:

Diagnosis is established by a neurological presentation unexplained by other diseases.
Evidence of systemic brucellar infection is required.
Inflammatory changes in CSF are a key diagnostic indicator.

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Main Results:

Neurobrucellosis diagnosis requires a combination of clinical, serological, and CSF findings.
Imaging findings in NB are diverse and can be categorized.
Imaging findings include normal scans, inflammation (granulomas, meningeal enhancement), white matter changes, and vascular abnormalities.

Conclusions:

Neurobrucellosis diagnosis is challenging due to nonspecific clinical and CSF findings.
Categorizing imaging findings aids in diagnosing NB.
Recognizing these imaging patterns is crucial for timely diagnosis and management of neurobrucellosis.