Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling the causes of Salmonella paratyphi B endemicity in Salta: A clinical-environmental perspective.

International journal of hygiene and environmental health·2025
Same author

Production and characterisation of four Joubert syndrome patient-derived induced pluripotent stem cell (iPSC) lines with mutations in either RPGRIP1L or CPLANE1 genes.

Stem cell research·2025
Same author

A low-dose multicomponent medication as a new approach in prevention and early add-on treatment of recurrent respiratory infections in children: a Delphi Consensus.

European review for medical and pharmacological sciences·2024
Same author

Impact of individual molecular components in determining primary sensitization to latex.

Immunobiology·2023
Same author

OM-85 in the prevention of respiratory infections: State-of-the-art and future perspectives in clinical practice.

Journal of biological regulators and homeostatic agents·2021
Same author

Latex allergy: advantages of molecular diagnostics during coronavirus.

Journal of biological regulators and homeostatic agents·2021

Related Experiment Video

Updated: May 28, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Gene-environment interaction in childhood asthma.

L Rigoli1, S Briuglia, S Caimmi

  • 1Department of Pediatrics, Unit of Pediatric Genetics and Immunology, University of Messina, Italy. carmelo.salpietro@unime.it

International Journal of Immunopathology and Pharmacology
|October 29, 2011
PubMed
Summary

Early life exposures and genetics significantly impact childhood asthma development. Gene-environment interactions, particularly involving the toll-like receptor-lipopolysaccharide pathway, influence asthma risk and allergic sensitization.

Related Experiment Videos

Last Updated: May 28, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Area of Science:

  • Environmental Health
  • Pediatric Allergy
  • Immunogenetics

Background:

  • Childhood asthma prevalence varies geographically and temporally, suggesting environmental influences.
  • Allergens, diet, and hygiene practices are implicated in asthma etiology.
  • Genetic factors modulate responses to environmental exposures like hygiene-related factors.

Purpose of the Study:

  • To review recent findings on gene-environment interactions in childhood asthma susceptibility.
  • To highlight the role of specific genetic variations in asthma development.
  • To explore mechanisms linking environmental exposures to asthma risk.

Main Methods:

  • Review of current scientific literature on asthma etiology.
  • Analysis of gene-environment interaction studies.
  • Focus on polymorphisms in the toll-like receptor-lipopolysaccharide (TLR-LPS) signaling pathway.

Main Results:

  • Gene-environment interactions are crucial in childhood asthma.
  • Polymorphisms in TLR-LPS pathway genes influence susceptibility to allergic sensitization.
  • Endotoxin exposure effects on asthma risk are modulated by genetic variations.

Conclusions:

  • Genetic variations, especially in the TLR-LPS pathway, play a key role in childhood asthma.
  • Understanding gene-environment interactions is vital for asthma prevention and treatment.
  • Early life environmental exposures interact with genetic predisposition to shape asthma risk.