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Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
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Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Published on: September 20, 2015

Probing ischemic tissue fate with BOLD fMRI of brief oxygen challenge

Qiang Shen1, Shiliang Huang, Fang Du

  • 1Research Imaging Institute, Department of Ophthalmology, Radiology and Physiology University of Texas Health Science Center, San Antonio, TX, USA.

Brain Research
|October 29, 2011
PubMed

Insights

Transient oxygen challenge (OC) reveals at-risk brain tissue in stroke models. Exaggerated T(2)⁎-weighted MRI signal increases during OC indicate metabolic activity in potentially salvageable tissue, aiding stroke assessment.

Area of Science:

  • Neuroimaging
  • Biomedical Engineering
  • Stroke Research

Background:

  • At-risk tissues show exaggerated T(2)⁎-weighted MRI signal increases during transient oxygen challenge (OC), indicating metabolic activity.
  • Previous studies suggest this phenomenon can identify metabolically active, potentially salvageable tissue.

Purpose of the Study:

  • To further characterize the effects of transient OC on T(2)⁎-weighted MRI in permanent focal stroke rats.
  • To investigate the relationship between OC response and tissue viability using quantitative MRI measures.

Main Methods:

  • Utilized T(2)⁎-weighted MRI with transient oxygen challenge in permanent focal stroke rat models (N=8).
  • Incorporated quantitative measures including T(1)-weighted imaging, cerebral blood flow (CBF), and diffusion-weighted imaging.
  • Analyzed T(2)⁎ signal changes in ischemic core, mismatch, and normal tissue regions.

Main Results:

  • The ischemic core showed no significant OC response, while the mismatch cluster exhibited higher percent signal changes.
  • Exaggerated OC responses, appearing hyperintense on T(2)-weighted MRI at 24h, were observed in a larger area than the diffusion-weighted imaging mismatch.
  • OC-induced changes diminished as perfusion and diffusion values fell below viability thresholds; basal T(1) increased in the core, and OC decreased T(1) and CBF in normal tissue.

Conclusions:

  • T(2)⁎-weighted MRI during OC can identify tissue at risk beyond the diffusion-weighted imaging mismatch in stroke.
  • This technique provides unique, clinically relevant data for assessing tissue viability and guiding stroke treatment.
  • The findings support the potential of OC-enhanced MRI for improved stroke diagnosis and management.

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