Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
Borderline Personality Disorder01:25

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Panic Disorder01:27

Panic Disorder

Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
Personality Disorders: Schizotypal and Histrionic01:20

Personality Disorders: Schizotypal and Histrionic

Schizotypal personality disorder and histrionic personality disorder are two distinct psychological conditions classified under personality disorders, each characterized by unique behavioral patterns and social difficulties. Both disorders significantly affect interpersonal relationships and emotional well-being, leading to social isolation and frustration.
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

La casa de papel: A pandemic in a pandemic.

Journal of affective disorders·2020
Same author

When and how to use lithium.

Acta psychiatrica Scandinavica·2020
Same author

Digital depression: a new disease of the millennium?

Acta psychiatrica Scandinavica·2020
Same author

Putting Codman's lesson to work: measuring and improving the quality of Italian mental health care.

Acta psychiatrica Scandinavica·2019
Same author

Updates in treating comorbid bipolar disorder and obsessive-compulsive disorder: A systematic review.

Journal of affective disorders·2019
Same author

Aripiprazole augmentation in treating comorbid bipolar disorder and obsessive-compulsive disorder: A systematic review.

Journal of affective disorders·2019
Same journal

Mapping topological abnormalities in cortical similarity networks to schizophrenia-associated gene expression.

Dialogues in clinical neuroscience·2026
Same journal

Poor sleep quality correlates with axial symptoms and mood problems in Parkinson's disease.

Dialogues in clinical neuroscience·2026
Same journal

Treatment of posttraumatic stress disorder (PTSD).

Dialogues in clinical neuroscience·2026
Same journal

Comparisons of thalamocortical functional connectivity in transgender women and cisgender individuals: associations with cognition in a Chinese cohort.

Dialogues in clinical neuroscience·2026
Same journal

The Arabic Generalized Anxiety Disorder 2 (GAD-2): Psychometric evaluation among mothers of children with intellectual disabilities.

Dialogues in clinical neuroscience·2026
Same journal

Polarisation of brain dynamics in mania and depression.

Dialogues in clinical neuroscience·2026
See all related articles

Related Experiment Video

Updated: May 28, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Bipolar disorder.

F K Goodwin1, S N Ghaemi

  • 1The Center on Neuroscience, Medical Progress, and Society Department of Psychiatry, George Washington University, Washington DC, USA.

Dialogues in Clinical Neuroscience
|October 29, 2011
PubMed
Summary
This summary is machine-generated.

Bipolar disorder research integrates genetics, neurobiology, and psychosocial factors. Understanding its complex nature is key to improving diagnosis and treatment outcomes for this psychiatric condition.

Keywords:
bipolar disorderdepressiondiagnosisgeneticsmanic-depressive illnessmood disorderneurobiologyoutcomeresearchtreatment

Related Experiment Videos

Last Updated: May 28, 2026

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Area of Science:

  • Psychiatry
  • Neuroscience
  • Genetics

Background:

  • Bipolar disorder holds a significant place in psychiatric history due to its genetic basis, distinct symptoms, and early effective treatment with lithium.
  • Its study drives current advancements in neuroscience.

Purpose of the Study:

  • To review the current state of knowledge on bipolar disorder across multiple domains.
  • To highlight the need for integrating biological and psychosocial research for future progress.

Main Methods:

  • Review of current research in bipolar disorder, covering genetics, diagnosis, outcomes, pathophysiology, treatment, neurobiology, and psychosocial aspects.
  • Focus on subjective diagnostic criteria to counter underdiagnosis.
  • Examination of treatment resistance and neurobiological mechanisms.

Main Results:

  • Genetic research points to potential linkages and polygenic models.
  • Diagnosis requires attention to subjective experiences to avoid underdiagnosis.
  • Emergence of treatment-resistant forms suggests a changing natural history.
  • Neurobiological research explores circadian rhythms, kindling, and second-messenger systems.
  • Anticonvulsants are emerging treatments, with concerns about antidepressant-induced resistance.

Conclusions:

  • Future advancements in understanding and treating bipolar disorder depend on integrating biological and psychosocial research.
  • A holistic approach, balancing psychopharmacological and psychotherapeutic strategies, is essential.