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Updated: May 28, 2026

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Published on: February 15, 2013
[Clinical safety paediatric patients]
J Requena1, J J Miralles, J Mollar
1Servicio de Medicina Preventiva, Hospital Universitari Sant Joan d'Alacant, Sant Joan d'Alacant, Spain. requena_jua@gva.es
Insights
Adverse events in hospitalized children occur at a rate of 3.61%, with medication-related events being most common. Understanding pediatric adverse event epidemiology is key to developing effective prevention strategies.
Area of Science:
- Pediatric healthcare outcomes
- Patient safety research
- Clinical epidemiology
Context:
- Adverse events (AEs) represent a significant concern in pediatric hospitalizations.
- Understanding the specific epidemiology of AEs in children is crucial for targeted interventions.
- Previous research has highlighted variations in AE rates across different age groups and healthcare settings.
Purpose:
- To determine the incidence and types of adverse events in pediatric hospitalizations.
- To identify preventable adverse events in children.
- To compare pediatric AE rates with those of non-elderly adults.
Summary:
- Analysis of three Spanish studies (ENEAS, EAPAS, Aragon) involving retrospective review of pediatric hospital records identified 29 AEs in 24 patients, occurring in 3.61% of hospitalizations.
- AE rates varied by age: 3.8% in infants, 4.0% in young children, and 2.6% in older children, all lower than the 6.4% rate in non-elderly adults.
- Medication-related events constituted the most frequent type (37.9%), and 65.5% of identified AEs were deemed preventable.
Impact:
- Findings underscore the distinct epidemiology of AEs in pediatric populations compared to adults.
- Knowledge of AE patterns in children can inform the development of specific prevention strategies.
- Reducing preventable AEs in hospitalized children is essential for improving patient safety and healthcare quality.
Objective:
To describe the incidence and types of adverse events in children and how they can be prevented.
Material And Methods:
Analysis of paediatric hospitalisations in the ENEAS Study, the Asturias Study on hospitalisation -related adverse events (EAPAS) and the Aragon Study of the Adverse Effects related to the hospitalisation, which involved a retrospective medical record review of a population-based, representative sample of all paediatric hospital discharges. Adverse events were defined as an injury caused by medical management, rather than by disease processes.
Results:
We were able to identify 24 paediatric patients suffering 29 AEs directly associated with medical care. Compared to non-elderly adult patients, infants and adolescents suffered lower rates of adverse events. Of these, 65.5% (19 AE) were considered as preventable. Adverse events occurred in 3.61% of paediatric hospitalisations. Adverse events rates were 3.8% in infants (0-1.5 years), 4.0% in children 1.5-6 years of age, and 2.6% in children 7-16 years of age, compared with a rate of 6.4% in non-elderly adults. Medication related (37.9%) events were the most common types of adverse event.
Conclusions:
The epidemiology of adverse events in children is different to that in adults. To reduce the adverse events that occur in hospitalized children, knowledge of AE epidemiology in paediatric patients will help in the development of prevention strategies to avoid or to minimise them.
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