Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased glucose transporter (GLUT4) protein expression in hyperthyroidism.

A Casla1, A Rovira, J A Wells

  • 1Department of Endocrinology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain.

Biochemical and Biophysical Research Communications
|August 31, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A ten-point plan for sustainable radiology: a commitment to action.

Radiologia·2026
Same author

ASNR-ESNR White Paper on Sustainability in Neuroradiology.

AJNR. American journal of neuroradiology·2026
Same author

Diagnostic pitfalls and complex cases in MS.

Revue neurologique·2026
Same author

Recommendations for the critical reading of clinical trials on disease-modifying drugs for multiple sclerosis.

Neurologia·2025
Same author

The value of manual MRI measurements of brain and spinal cord for daily clinical practice in multiple sclerosis subjects: A scoping review.

Multiple sclerosis and related disorders·2025
Same author

Synthetic MRI in Progressive MS: Associations with Disability.

AJNR. American journal of neuroradiology·2025
Same journal

NCF1 aggravates cerebral ischemia-reperfusion injury by amplifying NOX2-Dependent oxidative stress and inflammatory responses.

Biochemical and biophysical research communications·2026
Same journal

Functional and structural characterization of Akkermansia muciniphila thioredoxin domain-containing protein Amuc_2173.

Biochemical and biophysical research communications·2026
Same journal

SMURF1-mediated EFEMP1 ubiquitination reverses the resistance of HCC cells to sorafenib by promoting ferroptosis.

Biochemical and biophysical research communications·2026
Same journal

Development and validation of HSP90AA1 as a risk gene in a HIF-1α pathway-related prognostic signature for hepatocellular carcinoma.

Biochemical and biophysical research communications·2026
Same journal

Quercetin suppresses TGF-β1-induced proliferation and migration of vascular smooth muscle cells via the Smad2/3/MMP-9 signaling axis.

Biochemical and biophysical research communications·2026
Same journal

Biosynthesis, characterization and biological potential of microbe-mediated silver nanoparticles using thermophilic actinomycetes, Streptomyces nigra.

Biochemical and biophysical research communications·2026
See all related articles

Thyroid hormones significantly increase basal glucose uptake in skeletal muscle by boosting glucose transporter type 4 (GLUT-4) protein levels. This enhanced GLUT-4 expression contributes to increased peripheral glucose utilization in hyperthyroidism.

Area of Science:

  • Endocrinology
  • Metabolism
  • Molecular Biology

Background:

  • Thyroid hormones play a crucial role in regulating metabolism.
  • Skeletal muscle is a major site of glucose disposal.
  • The role of thyroid hormones in modulating skeletal muscle glucose uptake requires further elucidation.

Purpose of the Study:

  • To investigate the effect of hyperthyroidism on basal and insulin-stimulated skeletal muscle glucose uptake.
  • To determine the impact of thyroid hormones on the expression of the insulin-sensitive glucose transporter protein (GLUT-4) in skeletal muscle.

Main Methods:

  • Perfused hindquarter preparations from thyroxine-treated rats (hyperthyroid) and control rats were used.
  • Basal and insulin-stimulated glucose uptake were measured.

Related Experiment Videos

  • The abundance of GLUT-4 protein in skeletal muscle was quantified using Western blot analysis.

    • Main Results:

    • Basal glucose uptake was approximately twofold higher in hyperthyroid rats compared to controls.
    • Insulin-stimulated glucose uptake showed a reduced fold-increase in hyperthyroid rats, indicating decreased insulin responsiveness.
    • The abundance of GLUT-4 protein was significantly higher in the skeletal muscle of hyperthyroid rats.

    Conclusions:

    • Thyroid hormones increase basal skeletal muscle glucose uptake, partly due to an increment in GLUT-4 isoform expression.
    • Increased expression of muscle glucose transporter proteins may underlie the elevated peripheral glucose utilization observed in hyperthyroidism.
    • These findings highlight a direct impact of thyroid hormones on glucose transport mechanisms in skeletal muscle.