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Hydrolysis of synthetic chromogenic substrates by HIV-1 and HIV-2 proteinases
L H Phylip1, A D Richards, J Kay
1Department of Biochemistry, University of Wales College, Cardiff, U.K.
Biochemical and Biophysical Research Communications
|August 31, 1990
Abstract:
Kinetic constants (Km,Kcat) are derived for the hydrolysis of a number of chromogenic peptide substrates by the aspartic proteinase from HIV-2. The effect of systematic replacement of the P2 residue on substrate hydrolysis by HIV-1 and HIV-2 proteinases is examined.