Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

Drug Therapy

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

Diagnostic and Statistical Manual of Mental Disorders (DSM)

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...

Theoretical Approaches to Psychological Disorder

Theoretical Approaches to Psychological Disorder

The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Qualia as query act, the phenomenology of predictive error coding.

Frontiers in psychology·2025

Same author

Posttraumatic Distress Symptoms and Their Response to Treatment in Adults With Prolonged Grief Disorder.

The Journal of clinical psychiatry·2021

Same author

Medical comorbidity in complicated grief: Results from the HEAL collaborative trial.

Journal of psychiatric research·2017

Same author

Recommendations for Scientific Reports on Depression in Late Life.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2017

Same author

Clinical Research in the Managed Care Environment.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2017

Same author

Outcome Measures in Late-Life Depression.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2017

Search research articles

Related Experiment Video

Updated: May 28, 2026

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

Drug discovery and mental illness.

Barry D Lebowitz¹, Herbert W Harris

¹National Institute of Mental Health, Bethescla, Mel, USA.

Dialogues in Clinical Neuroscience

|October 29, 2011

Summary

Developing new mental disorder treatments requires a modern, mechanism-based approach. This involves integrating genetic and molecular medicine with updated clinical trial methods for better drug discovery.

Area of Science:

Neuroscience and Psychiatry
Pharmacology and Drug Discovery
Genetics and Molecular Medicine

Background:

Mental disorders represent a significant global health burden, causing substantial disability.
Existing medications for mental disorders, while effective, have limitations due to incomplete understanding of disease mechanisms.
The development of novel therapeutic strategies is hindered by a lack of deep pathophysiological insight.

Purpose of the Study:

To advocate for a paradigm shift in mental disorder drug discovery towards mechanism-based approaches.
To emphasize the integration of contemporary genetic and molecular tools in treatment development.
To highlight the necessity of modernizing clinical trial methodologies to align with new discovery paradigms.

Main Methods:

Keywords:

clinical trial drug development mechanism-based paradigm mental Illness

More Related Videos

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Published on: February 24, 2023

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Related Experiment Videos

Last Updated: May 28, 2026

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

Published on: December 4, 2014

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Published on: February 24, 2023

Developing a Rat Model for Bipolar Disorder

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Leveraging advanced tools from genetic and molecular medicine for a deeper understanding of mental disorder pathophysiology.
Implementing a mechanism-based drug discovery framework.
Revising and modernizing established clinical trial designs and methodologies.

Main Results:

The abstract does not present specific experimental results but outlines a proposed strategic direction for research.
It identifies the need for a paradigm shift in drug discovery for mental health conditions.
It emphasizes the synergy required between basic science advancements and clinical research practices.

Conclusions:

A mechanism-based approach, powered by genetic and molecular medicine, is crucial for advancing mental disorder treatments.
Modernizing clinical trial methodology is essential to effectively evaluate novel, mechanism-based therapies.
Integrating these advancements promises to overcome current limitations and accelerate the development of more effective treatments for disabling mental disorders.