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Protective effects of Allium paradoxum against gentamicin-induced nephrotoxicity in mice
Seyed Fazel Nabavi1, Seyed Mohammad Nabavi, Akbar Hajizadeh Moghaddam
1National Elites Foundation of Iran, Tehran 14174, Iran. Nabavi208@gmail.com
Abstract:
Allium paradoxum (M.Bieb.) G. Don is a locally known vegetable and is utilized for preparation a variety of local foods in northern of Iran. This study was conducted to quantitatively evaluate the recovery effects of A. paradoxum on gentamicin-induced nephrotoxicity in mice. The curative effect of extracts from the aerial parts and bulbs of A. paradoxum against gentamicin-induced renotoxicity in mice was determined. Both extracts at the dose 200 mg kg(-1) day(-1) offered nephroprotective effect by change in the blood urea nitrogen and creatinine. No statistical difference could be obtained in serum creatinine and blood urea nitrogen of bulb-treated mice compared to normal mice. The result show that bulb extract at 200 mg kg(-1) day(-1) has better activity than aerial parts.
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