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Related Experiment Video

Updated: May 28, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Neural models of schizophrenia.

¹Assistant Professor in Psychiatry, Harvard Medical School, Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA.

Dialogues in Clinical Neuroscience

|October 29, 2011

Summary

Psychosis symptoms like hallucinations and delusions stem from impaired sensory processing and neural circuit dysfunction in brain regions including the cortex and thalamus. This dysfunction may explain cognitive deficits in schizophrenia.

Keywords:

basal ganglia cortex medial temporal lobe neural model schizophrenia thalamus

Related Experiment Videos

Last Updated: May 28, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

Hallucinations and delusions are key psychosis symptoms in schizophrenia.
These symptoms relate to how the brain processes sensory information.

Purpose of the Study:

To describe the pathophysiology of hallucinations and delusions in psychosis.
To identify key brain systems and neurotransmitter pathways involved.

Main Methods:

Review of preliminary evidence focusing on neural circuitry.
Examination of brain regions like the cortex, thalamus, basal ganglia, and medial temporal lobe.

Main Results:

Hallucinations involve impaired internal/external source classification.
Delusions involve immutable, externally independent linking of representations.
Evidence points to neural circuitry dysfunction in psychosis affecting key brain systems.

Conclusions:

Dysfunction within and between the cortex, thalamus, basal ganglia, and medial temporal lobe may underlie psychosis symptoms.
This neural circuitry dysfunction may also explain associated cognitive deficits such as memory and attention impairments.