Related Experiment Video
Updated: May 28, 2026
08:54
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
[Neoadjuvant therapy concepts for liver metastases].
1Universitätskrebszentrum/Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Deutschland. Gunnar.Folprecht@uniklinikum-dresden.de
Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|October 29, 2011
Summary
Resecting liver metastases can lead to long-term survival for colorectal cancer patients. Combining surgery with chemotherapy, particularly FOLFOX, improves disease-free survival and response rates.
Area of Science:
- Oncology
- Surgical Oncology
- Gastrointestinal Oncology
Context:
- Colorectal carcinoma frequently metastasizes to the liver, impacting patient prognosis.
- Surgical resection of liver metastases offers a potential for long-term survival.
- Three clinical scenarios exist: resectable, potentially resectable, and disseminated liver metastases.
Purpose:
- To review treatment strategies for liver metastases in colorectal cancer based on resectability.
- To highlight the role of chemotherapy in conjunction with surgical resection.
- To discuss evidence-based neoadjuvant chemotherapy regimens.
Summary:
- Resectable liver metastases benefit from combined surgery and chemotherapy, with FOLFOX as a high-evidence neoadjuvant option.
- Potentially resectable metastases warrant regimens like FOLFIRI/cetuximab or FOLFOXIRI for improved response and resection rates.
- Regular reevaluation of resectability during neoadjuvant therapy is crucial for timely surgical planning.
Impact:
- Optimizing treatment strategies can improve survival outcomes for colorectal cancer patients with liver metastases.
- Evidence-based chemotherapy regimens enhance surgical success rates.
- Timely surgical intervention post-neoadjuvant therapy minimizes morbidity and addresses complete remission uncertainties.
More Related Videos
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...