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Phototherapy and photochemotherapy.

H Hönigsmann¹

¹Department of Dermatology I, University of Vienna, Austria.

Seminars in Dermatology

|March 1, 1990

Summary

This summary is machine-generated.

Ultraviolet (UV) radiation, including UVB phototherapy and UVA photochemotherapy, effectively treats various skin diseases like psoriasis and vitiligo. While beneficial, potential side effects, including skin cancer risk, require careful consideration.

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Area of Science:

Dermatology
Photobiology
Medical Physics

Background:

Ultraviolet (UV) radiation is a recognized modality for treating skin conditions.
Two primary methods, UVB phototherapy and UVA-based photochemotherapy with psoralens, are established in dermatologic practice.

Purpose of the Study:

To review current knowledge on UV radiation therapy for skin diseases.
To discuss indications, mechanisms, treatment outcomes, and side effects, including skin carcinogenesis.

Main Methods:

Literature review of existing research on phototherapy and photochemotherapy.
Analysis of treatment efficacy for various dermatoses and photodermatoses.

Main Results:

Photochemotherapy is a standard treatment for severe psoriasis, mycosis fungoides, and vitiligo.

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Phototherapy and photochemotherapy are effective for photodermatoses like polymorphic light eruption.

Both therapies have associated acute and chronic side effects, with a focus on skin cancer risk.

Conclusions:

UV radiation therapies, particularly photochemotherapy, are valuable in treating specific skin diseases.
Careful patient selection and monitoring are essential due to potential adverse effects.
Further research into mechanisms and long-term safety, especially regarding skin carcinogenesis, is warranted.