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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Articles linked to this work by shared authors, journal, and citation graph.

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Same author

[Dysmenorrhea].

Revue medicale de Bruxelles·2011
See all related articles

Related Experiment Video

Updated: May 28, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

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[Neoadjuvant therapy in breast cancer].

G Ena1

  • 1Service de Gynécologie-Obstétrique, Hôpital Erasme, Bruxelles. graziella.ena@erasme.ulb.ac.be

Revue Medicale De Bruxelles
|November 1, 2011
PubMed
Summary

Neoadjuvant therapy for breast cancer, including chemotherapy, hormonotherapy, and targeted treatments, offers equivalent survival outcomes to postoperative therapy. Pathologic complete response is a key predictor of long-term success in breast cancer management.

Area of Science:

  • Oncology
  • Breast Cancer Research
  • Translational Medicine

Context:

  • Neoadjuvant treatment is standard for inflammatory and locally advanced breast cancer.
  • It is also used for primary operable breast cancer to enable breast-conserving surgery.
  • This approach facilitates a deeper understanding of breast cancer biology.

Purpose:

  • To review the role of preoperative treatment in breast cancer management.
  • To discuss the evolution of neoadjuvant therapies beyond chemotherapy.
  • To highlight the significance of pathologic complete response as an outcome predictor.

Summary:

  • Neoadjuvant therapy, encompassing chemotherapy, hormonotherapy, and targeted treatments (e.g., trastuzumab for HER2+), yields survival outcomes comparable to postoperative regimens.

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  • While survival is equivalent, achieving pathologic complete response with neoadjuvant treatment indicates favorable long-term prognosis.
  • The neoadjuvant strategy is crucial for advancing breast cancer research and understanding tumor biology.

    • Impact:

    • Enhances understanding of breast cancer heterogeneity and treatment response.
    • Promotes the development of personalized treatment strategies.
    • Supports translational research by providing in-vivo drug sensitivity data.