Neurocognitive testing and functioning in adults sickle cell disease.

Area of Science:

• Neurology
• Hematology
• Psychology

Background:

• Cerebrovascular events (CVEs) significantly impact cognitive function and quality of life in adults with sickle cell disease (SCD).
• Understanding the neurocognitive sequelae of CVEs in SCD is crucial for patient care.
• Memory disturbances are a frequently reported concern among individuals with SCD.

Purpose of the Study:

• To investigate the prevalence and characteristics of memory disturbance in adults with SCD.
• To compare neurocognitive presentation between males and females with SCD.
• To explore the relationship between memory dysfunction and pain in SCD patients.

Main Methods:

• Survey methodology was used to assess memory complaints in 109 adult SCD patients.
• A subsample of 24 patients completed a specific memory questionnaire.
• Statistical analysis was performed to compare memory complaints between sexes and assess predictors of pain.

Main Results:

• No significant difference in memory disturbance frequency during painful crises between males and females with SCD.
• Men with SCD reported a greater decline in memory recall (object location, grocery items) compared to women.
• Men with SCD reported their memory was worse now than in high school more frequently than women.

Conclusions:

• Memory dysfunction is a significant issue in adults with SCD, with specific deficits more prevalent in men.
• Memory dysfunction appears to predict the global monthly presentation of pain in SCD patients.
• Routine, cost-effective neurocognitive screening is recommended for individuals with SCD.