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Factors controlling nanoparticle pharmacokinetics: an integrated analysis and perspective.
S M Moghimi1, A C Hunter, T L Andresen
1Centre for Pharmaceutical Nanotechnology and Nanotoxicology, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark. momo@farma.ku.dk
Annual Review of Pharmacology and Toxicology
|November 1, 2011
Summary
Nanoparticulate drug carriers offer targeted therapies within the body. Understanding nanoparticle properties is key to optimizing drug delivery, minimizing side effects, and advancing personalized nanomedicine.
Area of Science:
- Nanotechnology
- Materials Science
- Pharmacology
Background:
- Intravenously injected nanoparticulate drug carriers enable targeted delivery of therapeutics.
- Carrier pharmacokinetics and biodistribution depend on complex physicochemical and biological factors.
- Establishing clear relationships between nanoparticle characteristics and their biological fate is crucial.
Purpose of the Study:
- To critically evaluate the interdependencies of nanoparticle size, shape, and surface characteristics.
- To provide an integrated perspective on nanocarrier design and engineering using nanoscience.
- To explore the potential for personalized nanomedicines.
Main Methods:
- Nanoscience approaches applied to nanocarrier design and engineering.
- Critical evaluation of existing concepts and data.
- Integration of computational knowledge on genomics and epigenomics.
Main Results:
- Definitive maps outlining the interdependency of nanoparticle properties and biological outcomes are needed.
- Advances in nanoscience enable sophisticated nanocarrier design.
- Regulatory-approved nanomedicines and clinical trials indicate field progress.
Conclusions:
- Optimizing nanocarrier design requires understanding the interplay of physical properties and biological interactions.
- The field of nanomedicine is advancing rapidly with promising clinical applications.
- Personalized nanomedicines can be developed further by integrating genomic and epigenomic data.
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