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Regulation of platelet biology by platelet endothelial cell adhesion molecule-1

Chris I Jones1, Leonardo A Moraes, Jonathan M Gibbins

  • 1Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, UK. c.i.jones@reading.ac.uk

Platelets
|November 1, 2011
PubMed

Platelet endothelial cell adhesion molecule-1 (PECAM-1), an immunoreceptor tyrosine-based inhibitory motif containing receptor, plays diverse and apparently contradictory roles in regulating the response of platelets to stimuli; inhibiting platelet response to immunoreceptor tyrosine-based activation motif and G protein-coupled receptor signalling following stimulation with collagen, adenosine diphosphate, and thrombin, as well as enhancing integrin outside-in signalling. These dual, and opposing, roles suggest an important and complex role for PECAM-1 in orchestrating platelet response to vascular damage. Indeed, during thrombus formation, the influence of PECAM-1 on the multiple signalling pathways combines leading to a relatively large inhibitory effect on thrombus formation.

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