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Updated: May 28, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
Published on: February 27, 2026
Trunk weighted obesity, cholesterol levels and low grade inflammation are main determinants for enhanced thrombin
Florian Prüller1, Reinhard B Raggam, Verena Posch
1Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
Objective:
Endogenous thrombin generation (ETP) may be critically involved in obesity associated thromboembolism.
Methods:
Three hundred and one participants of the STyrian Juvenile OBesity (STYJOBS)/Early DEteCTion of Atherosclerosis (EDECTA) study cohort (age, 16-58years) were analysed. ETP was measured by the new CE-IVD marked Siemens-Innovance(®) ETP test on a BCS-XP analyser, and correlated to clinical findings and extended lipometry-based anthropometric data, biomarkers, and coagulation parameters.
Results:
In the overweight/obese study group, ETP and fibrinogen levels were significantly higher compared to controls (p<0.001). In a multiple stepwise regression including all subjects, subcutaneous adipose tissue thickness of upper back, cholesterol and ultrasensitive C-reactive protein were the best predictors for ETP.
Conclusion:
Trunk weighted obesity together with low grade inflammation and hypercholesterolemia enhance thrombin generation.
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