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Updated: May 28, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Effectiveness and use of linezolid in hospitalisation wards
R Rivas1, M Barrera, L González
1Servicio de Farmacia Hospitalaria, Hospital Juan Ramón Jiménez, Huelva, España. lukasiskariote@yahoo.es
Objective:
To describe the use and effectiveness of linezolid as an alternative treatment for methicillin-resistant Staphylococcus aureus.
Method:
Demographic, clinical and safety data were collected from hospitalised patients. The information sources were the clinical records and the pharmacy programme.
Results:
Thirty patients were treated with linezolid (median age 69.3, 63% male). The median duration of treatment was 8 days. The most prevalent indication was soft tissues and skin infections (46.7%). The indications were off-label in 40% of cases. Linezolid was used as a targeted therapy in 53%, especially for coagulase-negative Staphylococcus. Clinical healing occurred in 83.3%, and microbiological healing in 40%. Three patients (10%) experienced side effects from using linezolid.
Conclusion:
The effectiveness and safety of linezolid is similar to that described in the trials. Its off-label use and the high number of empirical treatments mean that new strategies must be developed.
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