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PNA to DNA to microarray decoding facilitates ligand discovery

Warren R J D Galloway1, David R Spring

  • 1Department of Chemistry University of Cambridge, Cambridge CB2 1EW, UK.

Chemistry & Biology
|November 1, 2011
PubMed

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...