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Updated: May 28, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Basophils in allergic immune responses.

David Voehringer¹

¹Department of Infection Biology, Institute for Medical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany. david.voehringer@uk-erlangen.de

Current Opinion in Immunology

|November 1, 2011

Summary

Basophils, rare innate immune cells, have unclear roles in allergic reactions. New mouse models yield conflicting data on their function in immunity against allergens and helminths.

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Area of Science:

Immunology
Innate Immunity
Allergic Responses

Background:

Basophils are rare effector cells of the innate immune system.
They are typically linked to type 2 immune responses, such as those seen in helminth infections and allergic reactions.
The precise role of basophils in initiating and executing allergic immune responses remains poorly understood.

Purpose of the Study:

To review current knowledge on basophil in vivo functions.
To focus on the role of basophils in allergic responses, including asthma, allergic skin diseases, and anaphylaxis.

Main Methods:

Utilized new tools for studying basophil function in mouse models.
Analyzed conflicting results obtained from different experimental systems.

Main Results:

Conflicting data exist regarding basophil involvement in the initiation and execution of immune responses against allergens and helminths.
New research tools have advanced the study of basophil function.

Conclusions:

Basophil functions in vivo, particularly in allergic diseases, require further elucidation.
Understanding basophil roles is crucial for developing targeted therapies for allergic conditions.