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Personalized participatory medicine: sharing knowledge and uncertainty.
David Gurwitz1, Jeantine E Lunshof
1Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel. gurwitz@post.tau.ac.il.
Genome Medicine
|November 1, 2011
Summary
Personalized medicine requires new patient-physician communication strategies. Genetic profiling, like CYP2D6 genotyping for breast cancer patients, aids treatment decisions.
Area of Science:
- Pharmacogenomics
- Oncology
- Medical Informatics
Background:
- Informing patients about complex treatment options and their risks/benefits is increasingly challenging.
- Growing knowledge links individual genetic profiles to medication efficacy and safety.
- Implementing personalized medicine necessitates novel information sharing and decision-making processes.
Purpose of the Study:
- To explore the practical application of personalized medicine in clinical decision-making.
- To illustrate challenges and solutions in patient-physician communication regarding genetic information and treatment choices.
- To examine treatment decisions in breast cancer patients undergoing CYP2D6 genotyping.
Main Methods:
- Case study analysis of breast cancer patients.
- Focus on genotyping for the CYP2D6 enzyme.
- Review of treatment selection processes informed by genetic data.
Main Results:
- Genetic profiling influences treatment choices for breast cancer patients.
- Effective communication strategies are crucial for integrating genetic information into clinical practice.
- The case study highlights the need for enhanced patient-physician dialogue.
Conclusions:
- Personalized medicine implementation requires adapting information sharing and decision-making models.
- CYP2D6 genotyping provides valuable data for tailoring breast cancer treatment.
- Future approaches must support informed choices based on genetic profiles.
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