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Updated: May 28, 2026
Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
Published on: January 4, 2019
Prospective randomized evaluation of a collagen/thrombin and autologous platelet hemostatic agent during total knee
Michael R Bloomfield1, Alison K Klika, Robert M Molloy
1Department of Orthopaedic Surgery-A41, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Abstract:
The purpose of this study was to evaluate the effectiveness of a collagen/thrombin and autologous platelet hemostatic agent in preventing blood loss during primary total knee arthroplasty. This prospective, double-blinded, randomized study was designed to enroll a total of 100 patients. Patients were randomized 1:1 to either the treatment arm (standard hemostasis plus study product) or the control arm (standard hemostasis alone). Transfusion requirements, as determined by a blinded investigator using standardized criteria, were significantly lower in the treatment group (no blood transfusions) compared with the control group (5 transfusions; P = .007). These data support the addition of the study product to prevent blood transfusions after primary total knee arthroplasty.