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Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: May 28, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

Emetine treatment masks initial LTP without affecting long-term stability.

Abdul-Karim Abbas¹, Fen-Sheng Huang, Rui Li

¹Department of Medical Biophysics, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden. abdul-karim.abbas@neuro.gu.se

|November 1, 2011

Summary

Pre-applying emetine, a protein synthesis inhibitor, to rat hippocampal slices showed that existing proteins are sufficient for stable long-term potentiation (LTP). Emetine

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Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

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Area of Science:

Neuroscience
Molecular Biology

Background:

Long-term potentiation (LTP) is a key mechanism for learning and memory.
The role of protein synthesis in establishing stable LTP is debated.

Purpose of the Study:

To investigate the necessity of protein synthesis for LTP induction.
To explore the effects of protein synthesis inhibitors on synaptic plasticity in rat hippocampal slices.

Main Methods:

Hippocampal slices from young rats were pre-treated with emetine, cycloheximide, or anisomycin.
Long-term potentiation (LTP) was induced and recorded.
The effects of NMDA receptor blocker AP5 were examined.

Main Results:

Emetine pre-treatment led to a slow-onset potentiation, distinct from standard LTP.
Stable LTP was maintained for up to 8 hours, suggesting preexisting proteins are sufficient.
Emetine, but not other inhibitors, impaired presynaptic function, causing a slow LTP onset.

Conclusions:

Preexisting proteins are sufficient for inducing stable long-term potentiation (LTP).
Emetine's effects on LTP onset are likely due to presynaptic impairment unrelated to protein synthesis inhibition.