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Updated: May 28, 2026

Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
Published on: May 23, 2025
The current state of hand transplantation
Jaimie T Shores1, Joseph E Imbriglia, W P Andrew Lee
1Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. jshores@jhmi.edu
Hand transplantation, a common composite tissue allotransplantation, offers life-changing outcomes. Success hinges on patient selection, surgical skill, rehabilitation, and careful immunotherapy to prevent rejection with minimal side effects.
Area of Science:
- Surgical innovation in reconstructive medicine.
- Transplant immunology and patient outcomes.
Background:
- Hand transplantation is the most frequent type of composite tissue allotransplantation.
- It necessitates a comprehensive multidisciplinary team approach.
Purpose of the Study:
- To highlight the key components for successful hand allotransplantation.
- To underscore the importance of patient selection and post-operative care.
Main Methods:
- Review of multidisciplinary team requirements for hand allotransplantation.
- Analysis of factors influencing functional outcomes and success rates.
Main Results:
- Functional outcomes can be transformative for selected patients.
- Increasing number of centers are offering this reconstructive option.
Conclusions:
- Successful hand transplantation relies on meticulous patient selection, surgical expertise, dedicated rehabilitation, and optimized immunotherapy.
- Balancing rejection prevention with acceptable morbidity is crucial for long-term success.
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