[Relationship between myocardial modelling and diastolic function in patients with essential hypertension]
Raquel Cortés1, Esther Roselló-Lletí, Manuel Portolés
1Unidad de Cardiocirculación, Hospital Universitario y Politécnico La Fe, Valencia, España.
Medicina Clinica
|November 1, 2011
Summary
In hypertensive patients with left ventricular hypertrophy, procollagen levels (PINP, PIIINP) and anti-apoptotic cytokines (sFas, sTNF-R1) were elevated. sFas and sTNF-R1 are independent predictors of PIIINP, linking myocardial fibrosis to diastolic dysfunction.
Area of Science:
- Cardiovascular Research
- Biomarkers in Hypertension
- Molecular Cardiology
Background:
- Hypertension is associated with cardiac remodeling and fibrosis.
- Understanding the molecular mechanisms of cardiac fibrosis is crucial for managing hypertensive heart disease.
- Procollagen peptides and apoptosis-related cytokines are potential indicators of myocardial changes.
Purpose of the Study:
- To investigate the relationship between procollagen peptides (PIIINP, PINP) and apoptosis-related cytokines (sFas, sTNF-R1) in hypertensive patients.
- To determine if these markers are associated with left ventricular hypertrophy and diastolic dysfunction.
- To identify independent predictors of myocardial fibrosis markers.
Main Methods:
- A cohort of 253 asymptomatic hypertensive patients was studied.
- Serum levels of PIIINP, PINP, sFas, and sTNF-R1 were measured.
- Echocardiography was performed to assess left ventricular structure and diastolic function.
Main Results:
- Patients with left ventricular hypertrophy showed significantly increased levels of PINP, PIIINP, sFas, and sTNF-R1 compared to those without hypertrophy.
- Serum PIIINP and PINP were positively correlated with sFas and sTNF-R1.
- sFas and sTNF-R1 were identified as independent factors related to serum PIIINP.
- All measured markers were significantly associated with left ventricular diastolic function parameters.
Conclusions:
- Elevated procollagen and anti-apoptotic cytokine levels are present in hypertensive patients with cardiac hypertrophy.
- sFas and sTNF-R1 are independently associated with PIIINP, suggesting a role in myocardial fibrosis.
- Diastolic dysfunction in hypertension is linked to myocardial fibrosis and anti-apoptotic cytokines.
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