Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Layers of Connective Tissue Proper01:21

Layers of Connective Tissue Proper

Fascia, a thin layer of fibrous connective tissue, is distributed throughout the body. It demarcates and forms a supportive covering over skeletal muscles, bones, blood vessels, and organs. There are three main types of facia— superficial fascia, deep fascia, and subserous fascia. These are all present at different depths in the body. Fascia reduces the friction and permits muscles, joints, and organs to easily slide against each other, facilitating movement of the body and preventing tearing...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Dissociative Amnesia01:21

Dissociative Amnesia

Dissociative amnesia is a complex psychological condition that manifests as an inability to recall personal information, often tied to traumatic or stressful events. Unlike general amnesia, individuals with this condition retain the ability to perform routine activities and procedural tasks, such as operating a phone or navigating public transportation, yet experience profound gaps in autobiographical memory. These lapses may encompass significant life events, such as suicide attempts or...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Invisible pain, visible change: the impact of multidisciplinary treatment on women with fibromyalgia.

Clinical and experimental rheumatology·2026
Same author

The Role of Obsessive Compulsive Traits in Fibromyalgia: Is Pain-Related Obsessive Ideation Involved in Pathogenesis?

Medicina (Kaunas, Lithuania)·2024
Same author

Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model.

Neuroscience and biobehavioral reviews·2023
Same author

Reply to: Hypothetical model ignores many important pathophysiologic mechanisms in fibromyalgia.

Nature reviews. Rheumatology·2023
Same author

Reply to 'Imbalance of threat and soothing systems in fibromyalgia: rephrasing an established mechanistic model?'

Nature reviews. Rheumatology·2023
Same author

Problem-oriented coping and resilience among Fibromyalgia patients who live under security threats and have undergone a Fibrotherapy intervention program.

Psychology, health & medicine·2023

Related Experiment Video

Updated: May 28, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
08:33

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

Is fibromyalgia a discrete entity?

Jacob N Ablin1, Dan Buskila, Boudewijn Van Houdenhove

  • 1Institute of Rheumatology and Internal Medicine F, Tel Aviv Sourasky Medical Center, Israel.

Autoimmunity Reviews
|November 1, 2011
PubMed
Summary

Fibromyalgia (FM) is a chronic widespread pain condition linked to central nervous system dysfunction. Diagnosis relies on clinical evaluation, not instrumental tests, emphasizing individualized patient care.

Related Experiment Videos

Last Updated: May 28, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers
08:33

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

Area of Science:

  • Rheumatology
  • Neurology
  • Pain Medicine

Background:

  • Fibromyalgia (FM) is a prevalent soft tissue pain syndrome characterized by chronic widespread pain (CWP) and altered pain sensitivity.
  • The exact pathogenesis of FM remains unclear, but current theories suggest a central nervous system (CNS) malfunction impacting pain signaling and perception.
  • FM diagnosis lacks specific instrumental tests, necessitating a thorough clinical assessment and patient history to exclude other conditions.

Purpose of the Study:

  • To define Fibromyalgia (FM) and its characteristics.
  • To discuss the current understanding of FM pathogenesis.
  • To highlight the diagnostic approach and the importance of individualized treatment.

Main Methods:

  • Clinical examination and patient history are primary diagnostic tools.
  • Differential diagnoses are excluded through comprehensive evaluation.
  • Assessment considers the full spectrum of patient tenderness and distress.

Main Results:

  • Fibromyalgia is identified as a distinct clinical entity.
  • Central nervous system (CNS) dysfunction is implicated in its pathophysiology.
  • Diagnosis is primarily clinical, excluding other potential causes.

Conclusions:

  • Fibromyalgia is characterized by chronic widespread pain and hypersensitivity.
  • Understanding the central nervous system's role is key to comprehending FM.
  • Tailoring treatment based on individual patient presentation is crucial for effective management.