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Updated: May 28, 2026
Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images
Published on: May 23, 2019
Guided delivery of adeno-associated viral vectors into the primate brain
Ernesto A Salegio1, Lluis Samaranch, Adrian P Kells
1Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94103–0555, USA.
Abstract:
In this review, we discuss recent developments in the delivery of adeno-associated virus-based vectors (AAV), particularly with respect to the role of axonal transport in vector distribution in the brain. The use of MRI-guidance and new stereotactic aiming devices have now established a strong foundation for neurological gene therapy to become an accepted procedure in interventional neurology.
