Fragrance material review on 2-phenoxyethanol

Area of Science:

• Toxicology
• Dermatology
• Fragrance Ingredient Safety

Background:

• 2-Phenoxyethanol belongs to the Aryl Alkyl Alcohols (AAAs) structural group.
• AAAs are diverse fragrance ingredients characterized by an alcohol group bonded to an aryl group.
• This review focuses on 2-phenoxyethanol, a primary alcohol within the AAA class.

Purpose of the Study:

• To conduct a toxicologic and dermatologic review of 2-phenoxyethanol.
• To summarize available safety data for 2-phenoxyethanol as a fragrance ingredient.
• To provide a comprehensive evaluation of the ingredient's properties and potential effects.

Main Methods:

• Evaluation of existing toxicology and dermatology research papers.
• Summarization of physical properties, acute toxicity, and irritation data.
• Review of sensitization, phototoxicity, toxicokinetics, and repeated dose toxicity studies.

Main Results:

• Compiled data on 2-phenoxyethanol's physical and toxicological properties.
• Assessed skin irritation, eye irritation, and skin sensitization potential.
• Included data on phototoxicity, photoallergy, toxicokinetics, and reproductive toxicity.

Conclusions:

• The review summarizes extensive data on 2-phenoxyethanol for fragrance applications.
• Findings contribute to the overall safety assessment of Aryl Alkyl Alcohols.
• Refer to Belsito et al. (2012) for a comprehensive safety assessment of AAAs.