Coping with parvovirus infections in mice: health surveillance and control
1Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Abstract:
Parvoviruses of mice, minute virus of mice (MVM) and mouse parvovirus (MPV), are challenging pathogens to eradicate from laboratory animal facilities. Due to the impediment on rodent-based research, recent studies have focused on the assessment of re-derivation techniques and parvoviral potential to induce persistent infections. Summarizing recent data, this review gives an overview on studies associated with parvoviral impact on research, diagnostic methods, parvoviral persistence and re-derivation techniques, demonstrating the complex nature of parvovirus infection in mice and unfolding the challenge of controlling parvovirus infections in laboratory animal facilities.
Insights
Controlling mouse parvoviruses (MVM and MPV) is difficult in research facilities. This review covers their impact on research, diagnostics, persistence, and re-derivation strategies for better management.
Area of Science:
- Laboratory animal science
- Virology
- Infectious disease control
Background:
- Mouse parvoviruses, minute virus of mice (MVM) and mouse parvovirus (MPV), are significant challenges in laboratory animal facilities.
- These viruses impede critical rodent-based research, necessitating effective control strategies.
- Persistent parvoviral infections are a hallmark of these pathogens in mouse populations.
Purpose of the Study:
- To review current data on the impact of MVM and MPV on laboratory research.
- To provide an overview of diagnostic methods for parvovirus detection.
- To summarize information on parvoviral persistence and re-derivation techniques in mice.
Main Methods:
- Literature review of recent studies on mouse parvoviruses.
- Synthesis of data concerning parvoviral impact, diagnostics, persistence, and re-derivation.
- Analysis of the challenges in controlling parvovirus infections in laboratory settings.
Main Results:
- Parvoviruses significantly disrupt rodent-based research.
- Effective diagnostic methods are crucial for early detection.
- Re-derivation techniques show promise but face challenges due to viral persistence.
- Controlling MVM and MPV requires a multifaceted approach.
Conclusions:
- Mouse parvovirus infections present a complex challenge for laboratory animal facilities.
- Understanding viral persistence and employing advanced re-derivation techniques are key to eradication.
- Continued research is needed to refine diagnostic and control strategies for MVM and MPV.
