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Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
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Pulmonary Tuberculosis II

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Related Experiment Video

Updated: May 28, 2026

Inducing Apical Periodontitis in Mice
10:26

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Periapical granuloma associated with extracted teeth.

F O Omoregie1, M A Ojo, Bdo Saheeb

  • 1Department of Oral and Maxillofacial Surgery and Pathology, University of Benin, Benin City, Nigeria. omoregiefo@yahoo.com

Nigerian Journal of Clinical Practice
|November 1, 2011
PubMed
Summary

Periapical granuloma is less common than previously reported. The acute phase shows foamy macrophages and lymphocytes, linked to acute apical periodontitis, suggesting a new classification based on inflammatory cells.

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Last Updated: May 28, 2026

Inducing Apical Periodontitis in Mice
10:26

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Published on: August 6, 2019

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
05:16

Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research

Published on: October 27, 2023

Area of Science:

  • Oral Pathology
  • Endodontics
  • Histopathology

Background:

  • Periapical granulomas are inflammatory responses to pulpal necrosis.
  • Understanding their incidence and histopathology is crucial for diagnosis.

Purpose of the Study:

  • To determine the incidence of periapical granuloma from extracted teeth.
  • To correlate clinical diagnoses with histopathological findings of periapical granuloma.

Main Methods:

  • Prospective study over eight months.
  • Routine biopsy of periapical tissues from single tooth extractions.
  • 136 patients included, 75 with periradicular lesions.

Main Results:

  • 23 cases (16.9%) of periapical granuloma identified.
  • Most common in the third and fourth decades (6.6%).
  • Acute apical periodontitis significantly associated with periapical granuloma (P<0.05), showing foamy macrophages and lymphocytes.

Conclusions:

  • Periapical granuloma incidence lower than previous reports.
  • Acute phase characterized by foamy macrophages/lymphocytes, not neutrophils.
  • Recommend classifying periapical granuloma stages based on inflammatory cells.