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Related Experiment Video

Updated: May 28, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

[HBV and pregnancy].

Salvatore Nardiello¹, Annarita Orsini, Ivab Gentile

¹Dipartimento di Medicina Interna e Specialistica, AOU Seconda Universita di Napoli, Italy.

Le Infezioni in Medicina

|November 1, 2011

Summary

This summary is machine-generated.

Hepatitis B virus (HBV) infection in pregnant women typically shows a mild clinical course, but flares are common post-delivery. Antiviral therapy in late pregnancy can reduce vertical transmission risks in high-risk cases.

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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

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Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface

Published on: December 30, 2025

Area of Science:

Hepatology
Infectious Diseases
Maternal-Fetal Medicine

Background:

Hepatitis B virus (HBV) infection during pregnancy often presents a similar clinical course to non-pregnant individuals.
Hepatitis flares are infrequent during pregnancy but common postpartum. HBV carrier status correlates with increased risks of gestational diabetes, preterm labor, and miscarriage.

Purpose of the Study:

To review the management of HBV infection in pregnant women.
To discuss the risks and benefits of antiviral therapy during pregnancy.
To highlight strategies for preventing neonatal HBV transmission.

Main Methods:

Literature review of HBV management in pregnancy.
Analysis of clinical outcomes and transmission risks.
Evaluation of immunoprophylaxis and antiviral therapy efficacy.

Main Results:

Hepatitis flares are rare during pregnancy but frequent postpartum.
HBV carrier status is linked to adverse pregnancy outcomes like gestational diabetes and preterm labor.
Neonatal immunoprophylaxis is highly effective but residual transmission risk exists with high maternal HBV DNA levels.

Conclusions:

Antiviral therapy in the third trimester can mitigate residual neonatal HBV transmission risk in high-viremic pregnant women.
Treatment decisions for pregnant women with HBV require balancing antiviral risks against hepatitis flare progression.
Effective neonatal immunoprophylaxis significantly reduces vertical HBV transmission.