Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Genetic Lingo01:11

Genetic Lingo

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Moving from information and collaboration to action: report from the 5th International Dog Health Workshop in Helsinki, June 2024.

Companion animal health and genetics·2026
Same author

Aberrant skeletal muscle morphogenesis and myofiber differentiation characterize equine myotonic dystrophy.

PloS one·2026
Same author

ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis.

Veterinary dermatology·2025
Same author

Identification of a Novel <i>CLPX</i> Variant in a Mixed-Breed Dog with Anemia and Spinocerebellar Ataxia.

Genes·2025
Same author

Identification of a novel RBCK1 splice site donor variant in Basset Hounds with glycogen storage disease myopathy.

Molecular genetics and metabolism·2025
Same author

Charting the equine miRNA landscape: An integrated pipeline and browser for annotating, quantifying, and visualizing expression.

PLoS genetics·2025
Same journal

Neuroinflammation in glaucoma: a myriad of cellular pathways and players.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Correction: THBS1: a biomarker for PCOS and its role in pathogenesis via the PI3K/AKT signaling pathway.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Elucidating the therapeutic targets and multi-target mechanisms of salvianolic acid A for diabetic nephropathy.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

DeepDisSNP: Predicting disease-associated SNPs by representation learning on disease and SNP linkage disequilibrium networks.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

A comprehensive full-length transcriptome atlas across multiple organs of an Indian yak breed-Arunachali.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Detection of a complex chromosomal rearrangement in a novel mouse mutant by optical genome mapping.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
See all related articles

Related Experiment Video

Updated: May 28, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

Canine epilepsy genetics.

Kari J Ekenstedt1, Edward E Patterson, James R Mickelson

  • 1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, 1352 Boyd Avenue, Saint Paul, MN 55108, USA. eken0003@umn.edu

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|November 1, 2011
PubMed
Summary
This summary is machine-generated.

Canine epilepsy research offers insights into human neurological disorders. While gene discovery is advancing for some canine epilepsies, complex forms like idiopathic epilepsy (IE) remain challenging to unravel genetically.

More Related Videos

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
08:26

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

Related Experiment Videos

Last Updated: May 28, 2026

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy
06:58

A Behavioral Screen for Heat-Induced Seizures in Mouse Models of Epilepsy

Published on: July 12, 2021

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
08:26

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

Area of Science:

  • Veterinary Genetics
  • Comparative Neurology
  • Canine Epilepsy Research

Background:

  • Dogs and humans share naturally occurring epilepsies with similar clinical features, making dogs valuable genetic models for human diseases.
  • While gene mutations have been identified for some inherited human epilepsies, many cases remain unexplained.
  • Canine epilepsy genetics also faces challenges, particularly in understanding polygenic forms, mirroring complexities seen in human and mouse models.

Purpose of the Study:

  • To review the current state of gene discovery in canine epilepsies.
  • To compare the genetic complexity of canine epilepsies with human and murine models.
  • To highlight the potential of canine epilepsy studies for understanding human neurological disorders.

Main Methods:

  • Review of existing literature on canine epilepsy genetics.
  • Comparison of gene discovery successes and challenges in progressive myoclonic epilepsies (PMEs) and idiopathic epilepsy (IE) in dogs.
  • Analysis of identified canine epilepsy genes and their relevance to human epilepsy research.

Main Results:

  • Gene mutations have been identified for eight canine progressive myoclonic epilepsies (PMEs), with six being orthologous to human disorders and two novel candidates for human studies.
  • Only one gene mutation (LGI2) has been described for canine idiopathic epilepsy (IE), linked to a specific breed and type of epilepsy, offering a novel candidate for human remitting childhood epilepsy.
  • Most studies on canine idiopathic epilepsy (IE) have failed to identify specific genes or loci, or have identified multiple quantitative trait loci (QTLs), indicating genetic complexity similar to human and mouse epilepsies.

Conclusions:

  • Canine epilepsy research, particularly in PMEs, has yielded valuable genetic insights, including novel candidates for human studies.
  • Idiopathic epilepsy (IE) in dogs presents significant genetic challenges, mirroring the complexity observed in human and murine epilepsies.
  • Despite ongoing challenges, canine epilepsy studies hold substantial promise for advancing our understanding of the genetic basis of neurological disorders in both species.