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Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
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The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Updated: May 28, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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[Plexiform fibrohistiocytic tumor].

L Pissoat1, M Megahed

  • 1Klinik für Allergologie und Dermatologie, Universitätsklinikum RWTH Aachen, Pauwelsstr. 30, 52074 Aachen. lpissoat@ukaachen.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|November 1, 2011
PubMed
Summary
This summary is machine-generated.

Plexiform fibrohistiocytic tumor, a rare soft-tissue neoplasm, typically affects young females. Complete surgical excision and long-term monitoring are crucial due to potential recurrence and metastasis risks.

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Area of Science:

  • Oncology
  • Pathology
  • Dermatology

Background:

  • Plexiform fibrohistiocytic tumor (PFT) is a rare soft-tissue neoplasm characterized by intermediate malignancy.
  • PFT predominantly affects pediatric and young adult females, presenting as a slow-growing nodule.

Observation:

  • A 6-year-old female presented with a six-month history of an indolent right axillary nodule.
  • Clinical examination and histopathological analysis confirmed the diagnosis of plexiform fibrohistiocytic tumor.

Findings:

  • The diagnosis was established based on established clinical and histopathological criteria for PFT.
  • The tumor exhibited characteristics consistent with plexiform fibrohistiocytic tumor.

Implications:

  • Surgical excision is recommended for PFT due to the potential for local recurrence.
  • Long-term follow-up is essential to detect nodal and pulmonary metastases promptly.