Related Experiment Videos

Precervical myositis ossificans in an infant secondary to child abuse

Jenna Harmon1, Andrew J Rabe, Kathleen K Nichol

  • 1The Ohio State University School of Medicine, Columbus, OH, USA.

Pediatric Radiology
|November 1, 2011
PubMed

Insights

Myositis ossificans circumscripta (MO) is rare in infants, especially in the neck. This case highlights a 10-week-old with MO due to nonaccidental trauma, detailing diagnosis and treatment.

Area of Science:

  • Pediatric Radiology
  • Pediatric Pathology
  • Musculoskeletal Imaging

Background:

  • Myositis ossificans circumscripta (MO) is a benign bone-forming tumor characterized by heterotopic ossification.
  • MO typically affects the extremities and is uncommon in infants, particularly in the head and neck region.
  • Nonaccidental trauma is an important, though infrequent, cause of MO in pediatric patients.

Observation:

  • A 10-week-old infant presented with a neck mass, suspected to be MO.
  • The clinical presentation suggested nonaccidental trauma as the etiology.
  • Imaging studies revealed a lesion in the neck consistent with MO.

Findings:

  • Ultrasound-guided biopsy was performed for diagnosis.
  • Pathological examination confirmed heterotopic ossification characteristic of MO.
  • Imaging findings demonstrated typical features of MO in an unusual location.

Implications:

  • This case underscores the importance of considering MO in infants with neck masses, even in rare locations.
  • Accurate diagnosis through imaging and biopsy is crucial for appropriate management.
  • Recognizing MO secondary to nonaccidental trauma is vital for child protection and timely intervention.

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...