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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

C-reactive protein as a predictor of cardiovascular events in elderly patients with chronic kidney disease

Diana Jalal1, Michel Chonchol, Thorleif Etgen

  • 1Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado 80045, USA. diana.jalal@ucdenver.edu

Journal of Nephrology
|November 1, 2011
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) and chronic kidney disease (CKD) independently increase vascular event risk in the elderly. Elevated hs-CRP offers prognostic value, particularly in individuals with CKD.

Area of Science:

  • Geriatric Medicine
  • Nephrology
  • Cardiology

Background:

  • Limited research exists on the link between high-sensitivity C-reactive protein (hs-CRP) and vascular events in elderly individuals with chronic kidney disease (CKD).
  • CKD is a growing concern in the elderly population, often coexisting with cardiovascular risk factors.

Purpose of the Study:

  • To investigate the association between hs-CRP levels and vascular events in the elderly, considering their CKD status.
  • To determine if hs-CRP provides additional prognostic information for vascular events in elderly patients with CKD.

Main Methods:

  • The study analyzed 3,166 participants from the INVADE study, assessing CKD (creatinine clearance <60 ml/min) and hs-CRP levels (> or <2.1 mg/L).
  • Vascular events were defined as a composite of myocardial infarction, stroke, and vascular death.
  • Follow-up duration was 4 years.

Main Results:

  • A total of 204 participants (6.4%) experienced a major cardiovascular event.
  • Both high hs-CRP levels and CKD at baseline were associated with an increased risk of vascular events.
  • The adjusted hazard ratio for vascular events was significantly higher in participants with both high hs-CRP and CKD compared to those with low hs-CRP and no CKD.

Conclusions:

  • High hs-CRP levels are a significant predictor of vascular events in the elderly.
  • These findings underscore the prognostic importance of hs-CRP in patients with CKD, highlighting a high-risk subgroup.
Abstract

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